FIGURE

Fig. 7

ID

ZDB-FIG-160421-14

Publication

Yelin-Bekerman et al., 2015 - Hypocretin neuron-specific transcriptome profiling identifies the sleep modulator Kcnh4a

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Fig. 7

Sleep time and quality are reduced in kcnh4a^-/- larvae during the night.

(A) The locomotor activity of kcnh4a^-/- (n=85), kcnh4a⁺^/- (n=208), and kcnh4a^+/+ (n=98) is shown. kcnh4a^-/- larvae exhibit increased locomotor activity compared with kcnh4a^+/- and kcnh4a / under LD conditions. (B) kcnh4a^-/- larvae showed a significant reduction in sleep time compared with kcnh4a^+/- and kcnh4a^+/+ during the night. Bar charts represent the average total locomotor activity (A′) and sleep time (B′) for each genotype. Values are represented as means ± SEM. (C,D) The number of sleep\wake transitions (C) and the length of sleep bout (D) are decreased in kcnh4a-/- larvae during the night. Recording of locomotor activity and sleep was performed in 6 dpf larvae continuously during 24 hr under a 14 hr light/10 hr dark cycle (white and black bars represent light and dark periods, respectively, *p<0.05, **p<0.01, ***p<0.0001, with repeated measures of ANOVA).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kcnh4a^biu8/biu8
Observed In:	circadian sleep/wake cycle, sleep locomotion involved in locomotory behavior regulation of circadian sleep/wake cycle, sleep
Stage:	Day 6

Phenotype Detail

Acknowledgments

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