FIGURE

Fig. 4

ID

ZDB-FIG-160414-13

Publication

Langdon et al., 2016 - Split top: A maternal cathepsin B that regulates dorsoventral patterning and morphogenesis

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Fig. 4

BMP misexpression rescues split top mutants and endogenous BMP signaling is functional. (A) bozozok and (B) squint expression (sphere stage: animal view, dorsal to right). (C) bmp2b expression at shield (lateral view, dorsal to right) and mid-gastrulation. (D-G) Representative phenotypes and bar graphs of uninjected and bmp2b (D,E) or bmp7a (F,G) mRNA injected wild-type and split top mutant embryos. (H,I) Representative phenotypes and bar graphs of wild-type and split top mutant embryos uninjected or injected with chordin, noggin and fstl1b morpholinos (CNF MO).

Expression Data

Genes:	bmp2b dharma ndr1
Fish:	TL ctsba^p24bdth/+ (TL)
Anatomical Terms:	margin shield whole organism dorsal region whole organism ventral region
Stage Range:	Sphere to 75%-epiboly

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ctsba^p24bdth/+ (TL) TL + MO1-chrd + MO1-fstl1b + MO1-nog1 ctsba^p24bdth/+ + MO1-chrd + MO1-fstl1b + MO1-nog1 (TL)
Knockdown Reagents:	MO1-chrd MO1-fstl1b MO1-nog1
Observed In:	shield whole organism whole organism cytolysis whole organism ventral region yolk
Stage Range:	Shield to Prim-5

Phenotype Detail

Acknowledgments

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