FIGURE

Fig. 1

ID

ZDB-FIG-151214-37

Publication

Hernández-Bejarano et al., 2015 - Opposing Shh and Fgf signals initiate nasotemporal patterning of the retina

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Fig. 1

Lack of Hh signalling results in loss of temporal fate. (A) Schematic of early (left) and late (right) organisation of nasotemporal (NT) domains in the developing eye. Note that the NT axis, initially aligned with the DV axis of the embryo, rotates and becomes aligned with the AP axis as development proceeds. Red, temporal domain; green, nasal domain; blue, Shh source. (B-M) Dorsal with anterior to the left (B,D,F-H,J) and frontal (C,E,I,K-M) views of forebrain and eyes showing expression of foxd1 (B,C,F,H,I,L) and foxg1 (D,E,G,J,K,M) in the genotypes and treated conditions specified in the panels. All embryos were 10-12ss other than those shown in L and M, which were 5ss. (N,O) Schematic representations of the phenotypic outcome of foxg1/foxd1 expression in wild-type (N) and lack of Shh (O) conditions. Scale bars: 100µm. Numbers in the bottom-right of each panel indicate the number of embryos with the phenotype shown out of the total number of embryos analysed. n, nasal; t, temporal; t*, defective temporal domain. Dashed lines outline the forebrain (dorsal views) or the optic vesicles (frontal views).

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Phenotype Data

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