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Fig. S1

ID

ZDB-FIG-151002-37

Publication

Cavanaugh et al., 2015 - Two developmentally distinct populations of neural crest cells contribute to the zebrafish heart

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Fig. S1

(A-B) Wide field image of embryo treated with DMSO (A) and SU5402 (B) from 16-48 hpf. (C-D) Confocal projection of a lateral view of the anterior region of NC:NfsB-mCherry; myl7:nucGFP embryo treated with DMSO (C) or SU5402 (D) from 16-48 hpf (anterior toward top). Inhibition of FGF signaling by SU5402 treatment resulted in a small ventricle and diminished NC contribution in the pharynx PA1 and PA2. Brackets indicate more posterior PAs. Scale bar=40 µm. (E-F′′) Confocal projection of the ventral view of NC:mCherry; kdrl:GFP embryos at 72 hpf. Scale bar=20 µm. (E-E′′) In DMSO-treated control embryos, the VA and BA are clearly defined and have normal contribution from mCherry positive cells. (F-F′′) SU5402 treatment perturbed VA and BA formation (note absence of kdrl:GFP) and abolished the contribution of mCherry positive in the region. The weak GFP signals in cells of non-sox10 lineages are from the ubi:switch transgene of NC:mCherry. Brackets indicate the ventral aorta. BA, bulbus arteriosus; V, ventricle.

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Acknowledgments

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Reprinted from Developmental Biology, 404(2), Cavanaugh, A.M., Huang, J., Chen, J.N., Two developmentally distinct populations of neural crest cells contribute to the zebrafish heart, 103-12, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.