FIGURE

Fig. 4

ID

ZDB-FIG-150507-3

Publication

Benini et al., 2015 - slc7a6os Gene Plays a Critical Role in Defined Areas of the Developing CNS in Zebrafish

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Fig. 4

Morphological analysis of slc7a6os morphants and phenotypic rescue at 48 h.

At 48 hpf, lateral view show that MO injected embryos have an evident pericardial and yolk-sac edema and the somite structures are not well-defined (D-E) when compared to controls (A, D). Dorsal view of morphants shows that the CNS abnormalities are more pronounced and reveals a severe disorganization of the following structures: midbrain–hindbrain boundary, dorsal diencephalon and tegmentum (F). Also at this developmental stage the expression of synthetic slc7a6os mRNA rescues the wild type phenotype in morphants (G-I). Abbreviations: so, somites; teg, tegmentum; dd, dorsal diencephalon; MHB, midbrain–hindbrain boundary.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-slc7a6os
Knockdown Reagent:	MO1-slc7a6os
Observed In:	central nervous system diencephalon midbrain hindbrain boundary pericardium somite tegmentum yolk syncytial layer
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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