FIGURE

Fig. 5

ID

ZDB-FIG-150422-35

Publication

Stooke-Vaughan et al., 2015 - Otolith tethering in the zebrafish otic vesicle requires Otogelin and α-Tectorin

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Fig. 5

Normal macular development is required for normal expression of otog and tecta. (A) otog mRNA expression at the poles of the OV of a 21hpf wild-type (LWT strain) OV. (B) Expression of otog was reduced in the OV of atoh1b morphants. (C) Expression of tecta at the poles of a 21hpf wild-type OV. (D) tecta expression was not detected in the OV of atoh1b morphants. (E) otog expression in the utricular macula of a 31hpf phenotypically wild-type sibling embryo. (F) otog expression was reduced in the utricular macula of a 31hpf mib mutant embryo. (G) tecta expression in the utricular macula of a 31hpf phenotypically wild-type sibling embryo. (H) tecta expression was reduced in the utricular macula of a 31hpf mib mutant embryo. Weak expression remained in the saccular macula (out of focus). Dorsal (A-D) and lateral (E-H) views, with anterior to left. Scale bar: 50µm for A-H.

Expression Data

Genes:	otog tecta
Fish:	WT mib1^ta52b/ta52b WT + MO1-atoh1b
Knockdown Reagent:	MO1-atoh1b
Anatomical Terms:	macula utricle otic vesicle anterior region otic vesicle posterior region
Stage Range:	20-25 somites to Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mib1^ta52b/ta52b WT + MO1-atoh1b
Knockdown Reagent:	MO1-atoh1b
Observed In:	auditory epithelial support cell hair cell otic vesicle tether cell
Stage Range:	20-25 somites to Prim-15

Phenotype Detail

Acknowledgments

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