Gene
otog
- ID
- ZDB-GENE-120228-1
- Name
- otogelin
- Symbol
- otog Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable alpha-L-arabinofuranosidase activity and structural molecule activity. Acts upstream of or within otolith formation; otolith tethering; and proprioception. Predicted to be located in extracellular region. Is expressed in otic vesicle and vestibuloauditory system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 18B. Orthologous to human OTOG (otogelin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 26 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa10228 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16704 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17990 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18441 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18470 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21033 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21034 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34131 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40966 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40967 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 18B | Alliance | Deafness, autosomal recessive 18B | 614945 |
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Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-223L2 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068222445 (1) | 10455 nt | ||
| Genomic | GenBank:BX842701 (2) | 172765 nt | ||
| Polypeptide | RefSeq:XP_068078546 (1) |
- Comparative Orthology
- Alliance
- Sun, P., Smith, E., Nicolson, T. (2023) Transmembrane channel-like (Tmc) subunits contribute to frequency sensitivity in the zebrafish utricle. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(1):
- Hamling, K.R., Zhu, Y., Auer, F., Schoppik, D. (2022) Tilt In Place Microscopy (TIPM): a simple, low-cost solution to image neural responses to body rotations. The Journal of neuroscience : the official journal of the Society for Neuroscience. 43(6):936-948
- Jones, A.A., Diamantopoulou, E., Baxendale, S., Whitfield, T.T. (2022) Presence of chondroitin sulphate and requirement for heparan sulphate biosynthesis in the developing zebrafish inner ear. Frontiers in cell and developmental biology. 10:959624
- Liu, Z., Kimura, Y., Higashijima, S.I., Hildebrand, D.G.C., Morgan, J.L., Bagnall, M.W. (2020) Central Vestibular Tuning Arises from Patterned Convergence of Otolith Afferents. Neuron. 108(4):748-762.e4
- Ehrlich, D.E., Schoppik, D. (2019) A primal role for the vestibular sense in the development of coordinated locomotion. eLIFE. 8:
- Kalka, M., Markiewicz, N., Ptak, M., Sone, E.D., Ożyhar, A., Dobryszycki, P., Wojtas, M. (2019) In vivo and in vitro analysis of starmaker activity in zebrafish otolith biomineralization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(6):6877-6886
- Thiessen, K.D., Grzegorski, S.J., Chin, Y., Higuchi, L., Wilkinson, C.J., Shavit, J.A., Kramer, K.L. (2019) Zebrafish otolith biomineralization requires polyketide synthase. Mechanisms of Development. 157:1-9
- Roberts, R., Elsner, J., Bagnall, M.W. (2017) Delayed Otolith Development Does Not Impair Vestibular Circuit Formation in Zebrafish. Journal of the Association for Research in Otolaryngology : JARO. 18(3):415-425
- Schwarzer, S., Spieß, S., Brand, M., Hans, S. (2017) Dlx3b/4b is required for early-born but not later-forming sensory hair cells during zebrafish inner ear development. Biology Open. 6(9):1270-1278
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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