FIGURE

Fig. 6

ID

ZDB-FIG-150416-36

Publication

Sallin et al., 2015 - A dual epimorphic and compensatory mode of heart regeneration in zebrafish

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Fig. 6

EmbCMHC-expressing CMs integrate with both the provisional fibrotic tissue and mature myocardium. (A–F) Sections of cmlc2::EGFP hearts at 7 dpci immunostained with antibody against Fibronectin (A,B), Tenascin C (C,D) and Connexin 43 (E,F). The post-infarcted tissue (PIT) is encircled with dashed line. (B′–F′′) Higher magnifications of the framed areas in the left panels. EmbCMHC-positive cells are embedded in the network of the extracellular matrix (ECM) fibers (green) produced by the fibrotic tissue at the myocardial border (B′–D′′). (F′,F′′′) The tight junctions protein, Connexin 43, is strongly upregulated in the juxtaposed mature (embCMHC-negative) and undifferentiated (embCMHC-positive) CMs, indicating the electrical coupling between both types of myocytes. Scale bar (A, B′, B′′)=50 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 399(1), Sallin, P., de Preux Charles, A., Duruz, V., Pfefferli, C., Jazwinska, A., A dual epimorphic and compensatory mode of heart regeneration in zebrafish, 27-40, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.