FIGURE

Fig. 5

ID

ZDB-FIG-150406-45

Publication

Sun et al., 2015 - Myc-Induced Liver Tumors in Transgenic Zebrafish Can Regress in tp53 Null Mutation

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Fig. 5

Accelerated liver tumor progression of mycAG fish in homozygous tp53^M214K background (AG53).

MycAG and AG53 fish were induced by 2 µM mifepristone from 1 mpf and sampled at 0.5 mpi and 1.5 mpi for gross observation and histological examination, as indicated at the top of the figure. (A1–A5) Exterior observation of each phenotype. (B1–B5) Gross observation of liver tumors after removal of body wall. (C1 to C5) The same views as those in (B1–B5) for observation of GFP expression that illustrate the shape of livers. (D1–D5) H&E staining of liver sections.

Expression Data

Gene:	EGFP
Fish:	gz23Tg gz23Tg; gz27Tg tp53^zdf1/zdf1; gz23Tg; gz27Tg
Condition:	chemical treatment: pharmaceutical
Anatomical Term:	liver
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gz23Tg; gz27Tg tp53^zdf1/zdf1; gz23Tg; gz27Tg
Condition:	chemical treatment: pharmaceutical
Observed In:	hepatocyte hepatocyte nucleus liver whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

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