FIGURE

Fig. 6

ID

ZDB-FIG-150121-9

Publication

Fischer et al., 2003 - The zebrafish fgf24 mutant identifies an additional level of Fgf signaling involved in vertebrate forelimb initiation

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Fig. 6

fgf24 acts downstream of wnt2b and tbx5, and upstream of fgf10. (A) Wild-type fgf24 expression at 24 hpf. (B) fgf24 expression in a tbx5-morpholino knockdown embryo (tbx5mo) at 24 hpf. (C) fgf24 expression in a wnt2b-morpholino knockdown embryo (wnt2bmo) at 24 hpf. (D) Wild-type fgf10 expression at 24 hpf. (E) fgf10 expression in the absence of fgf24 activity at 24 hpf. (F) Schematic representation of the hierarchy of genes involved in triggering limb development. Scale bar: 50 µm. All photos are at the same magnification.

Expression Data

Genes:	fgf10a fgf24
Fish:	WT fgf24^{t22030/t22030} WT + MO1-tbx5a WT + MO2-wnt2ba
Knockdown Reagents:	MO1-tbx5a MO2-wnt2ba
Anatomical Term:	pectoral fin bud
Stage:	Prim-5

Expression Detail

Gene	Fish	Conditions	Stage	Qualifier	Anatomy	Assay
fgf10a	WT	standard conditions	Prim-5		pectoral fin bud	ISH
fgf10a	fgf24^{t22030/t22030}	standard conditions	Prim-5	Not Detected	pectoral fin bud	ISH
fgf24	WT	standard conditions	Prim-5		pectoral fin bud	ISH
fgf24	WT + MO1-tbx5a	standard conditions	Prim-5	Not Detected	pectoral fin bud	ISH
fgf24	WT + MO2-wnt2ba	standard conditions	Prim-5	Not Detected	pectoral fin bud	ISH

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Antibody Labeling

Phenotype Data

Fish:	fgf24^{t22030/t22030} WT + MO1-tbx5a WT + MO2-wnt2ba
Knockdown Reagents:	MO1-tbx5a MO2-wnt2ba
Observed In:	pectoral fin bud
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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