Gene

fgf10a

ID

ZDB-GENE-030715-1

Name

fibroblast growth factor 10a

Symbol

fgf10a Nomenclature History

Previous Names

fgf10
dae
daedalus
wu:fd11d03 (1)
zgc:109774

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable chemoattractant activity; growth factor activity; and type 2 fibroblast growth factor receptor binding activity. Acts upstream of or within several processes, including embryonic pectoral fin morphogenesis; posterior lateral line development; and regulation of hematopoietic stem cell differentiation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including ectoderm; fin bud; gut; head; and lateral line system. Human ortholog(s) of this gene implicated in LADD syndrome and aplasia of lacrimal and salivary glands. Orthologous to human FGF10 (fibroblast growth factor 10).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

98 figures from 60 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:109774 (13 images)
eu110 (19 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 17 figures from 11 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fgf10a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
aplasia of lacrimal and salivary glands	Alliance	Aplasia of lacrimal and salivary glands	180920
lacrimoauriculodentodigital syndrome 3	Alliance	LADD syndrome 3	620193

Associated With fgf10a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR002209	Fibroblast growth factor family
Homologous_superfamily	IPR008996	Cytokine IL1/FGF

Domain Details Per Protein

Protein	Length	Cytokine IL1/FGF	Fibroblast growth factor family
UniProtKB:Q8AY90 InterPro	201

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	fgf10a-201 (1) Ensembl	Ensembl		2,005 nt	Select Tool ZFIN BLAST
mRNA	fgf10a-202 (1) Ensembl	Ensembl		2,383 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations