FIGURE
Fig. S11
- ID
- ZDB-FIG-141007-53
- Publication
- Bielczyk-Maczyńska et al., 2014 - A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis
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Fig. S11
To assess the HSC emergence in the aorta-gonad-mesonephros (AGM) region, we injected gene-specific MOs in single-cell stage Tg(c-myb:GFP) transgenic embryos. For kalrn1, mfn2, pdia5, psmd13 and wasplb MO injected embryos no difference in the number of HSCs was observed when compared to the control at 30 hpf. However, kalrn2 and rcor1 depleted embryos had a marked decrease in the number of HSCs at 30 hpf, implying an important role of these genes in specification of HSCs in the AGM. Representative images of the AGM region are shown. All embryos are oriented with anterior to the left and dorsal to the top. |
Expression Data
| Gene: | |
|---|---|
| Fish: | |
| Knockdown Reagents: | |
| Anatomical Term: | |
| Stage: | Prim-15 |
Expression Detail
Antibody Labeling
Phenotype Data
| Fish: | |
|---|---|
| Knockdown Reagents: | |
| Observed In: | |
| Stage: | Prim-15 |
Phenotype Detail
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