FIGURE

Fig. 5

ID

ZDB-FIG-140910-28

Publication

Heijnen et al., 2014 - Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway

Other Figures

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Fig. 5

RP loss results in a decrease of IRS1 and phosphorylated AKT substrates. (A) Western blot analysis of IRS1 in GFP-LC3 HEK cells transfected with siScr or siRPS19. (B) Western blot analysis of phosphorylated AKT substrates in GFP-LC3 HEK cells transfected with siScr or siRPS19 and either untreated or stimulated with 350 nM insulin for 6 hours. (C) Densitometer analysis of the total expression level of phosphorylated AKT substrates in (B). (D) Western blot analysis of phosphorylated AKT substrates in 2 dpf zebrafish embryos.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rpl11^{hi3820bTg/hi3820bTg} rps3a^{hi1290Tg/hi1290Tg} rps7^{hi1034bTg/hi1034bTg}
Observed In:	phosphatidylinositol 3-kinase/protein kinase B signal transduction
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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