FIGURE

Fig. 4

ID

ZDB-FIG-140910-25

Publication

Heijnen et al., 2014 - Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway

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Fig. 4

RP loss increases phospo-S6 kinase signaling. (A) Western blot analysis showing the expression of phosphorylated S6 kinase in GFP-LC3 HEK cells transfected with siScr or siRPS19 and either untreated or treated with 100 nM rapamycin overnight. (B) Western blot analysis of phosphorylated S6 kinase expression in CD34⁺ cord blood cells infected with a control shRNA (shScr) or an shRNA against RPS19 (shRPS19). (C) Western blot analysis of phosphorylated S6 kinase expression in LCLs derived from a normal control or DBA patients. (D) Western blot analysis of phosphorylated S6 kinase expression in 2 dpf zebrafish embryos.

Expression Data

Antibody:	Ab6-rps6k
Fish:	WT rpl11^{hi3820bTg/hi3820bTg} rps3a^{hi1290Tg/hi1290Tg} rps7^{hi1034bTg/hi1034bTg}
Anatomical Term:	whole organism
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rpl11^{hi3820bTg/hi3820bTg} rps3a^{hi1290Tg/hi1290Tg} rps7^{hi1034bTg/hi1034bTg}
Observed In:	ribosomal protein S6 kinase activity
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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