FIGURE

Fig. 3

ID

ZDB-FIG-140909-30

Publication

Apschner et al., 2014 - Pathological mineralization in a zebrafish enpp1 mutant exhibits features of Generalized Arterial Calcification of Infancy (GACI) and Pseudoxanthoma Elasticum (PXE)

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Fig. 3

Treatment with the pyrophosphate analog etidronate rescues aspects of the dgf phenotype. (A) Measurements (in pixel area) of the mineralized area in the axial skeleton of Alizarin-Red- and Alcian-Blue-stained siblings (sibs; left panel) and mutants (right panel), which were either untreated (blue) or treated with 100 μM Etidronate (green). A2 indicates the region of interest that was measured for the analysis. No significant difference (ns) occurs in siblings (A,B left panels); in treated dgf mutants, the mineralized area was significantly reduced when compared with untreated dgf mutants (A,B right panels). n=50 (dgf 100 μM Etidronate); n=48 (dgf control); n= 24 (siblings 100 μM Etidronate); n=24 (siblings control).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT enpp1^{hu4581/hu4581}
Condition:	chemical treatment: pharmaceutical
Observed In:	notochord notochord bone mineralization
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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