Fig. 4
- ID
- ZDB-FIG-131017-10
- Publication
- MacDonald et al., 2013 - The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon
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The expression of gad1b is impaired in the prethalamus but not in the telencephalon of ascl1a morphants and of dlx1a/2a double morphants at 48 hpf. Lateral (A–D) and dorsal views (A′–D′) of the forebrain of control and morphant embryos. (A) Expression of gad1b in embryos injected with the control morpholino is seen in the telencephalon (Tel), prethalamic (Pth) and hypothalamic (Hy) diencephalon. (B) Morpholino knockdown of ascl1a results in a loss of ventral prethalamic (dashed box) and hypothalamic (asterisk) gad1b expression. (C) Double morpholino knockdown of dlx1a/2a results in decreased prethalamic and hypothalamic gad1b expression. (D) In dlx5a/dlx6a morphants there is mild reduction of prethalamic and a decrease in hypothalamic gad1b expression similar to that observed in ascl1a and dlx1a/2a morphants. Dashed line indicates telencephalon-diencephalon boundary. Scale bar=50 μm. |
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Reprinted from Developmental Biology, 381(1), MacDonald, R.B., Pollack, J.N., Debiais-Thibaud, M., Heude, E., Talbot, J.C., and Ekker, M., The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon, 276-85, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.