FIGURE

Fig. 6

ID

ZDB-FIG-130103-12

Publication

Comyn et al., 2012 - Lack of Developmental Redundancy between Unc45 Proteins in Zebrafish Muscle Development

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Fig. 6

Skeletal defects in unc45 mutants at 5 dpf.

Ventral views of Alcian Blue stained cartilages (a–d). Wild type siblings (a), unc45a^-/- (b), unc45b^-/- (c), and unc45b^-/-; unc45a^-/- (d) mutants. Wild type siblings and unc45a^-/- mutants (a,b) have robust cartilage staining whereas unc45b^-/- (c) and unc45b^-/-; unc45a^-/- (d) mutants exhibit decreased staining, improper angling of the ceratohyal cartilages, and shortening of the palatoquadrates and Meckel′s cartilage. The pectoral girdle (arrows) is missing or reduced in unc45b^/ (c) and unc45b^-/-; unc45a^-/- (d) embryos. cb, ceratobranchial; ch, ceratohyal; hs, hyosymplectic; mc, Meckel′s cartilage; pq, palatoquadrate. Small blue dots are an artifact of the fixation and staining process.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	unc45b^sb60/sb60 unc45a^tr12/tr12; unc45b^sb60/sb60
Observed In:	ceratohyal cartilage Meckel's cartilage palatoquadrate cartilage pectoral girdle
Stage:	Day 5

Phenotype Detail

Acknowledgments

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