FIGURE

Fig. 5

ID

ZDB-FIG-121203-11

Publication

Chen et al., 2012 - MANF regulates dopaminergic neuron development in larval zebrafish

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Fig. 5

Knockdown of manf did not alter the serotonergic system, GABAergic system, hdc and hcrt expression in manf deficient embryos. (A and B) 5-HT and (C and D) GABA immunostainingin control MO and manf MOsp morphants in 5 dpf brains. (E) The serotonin level and (F) the epinephrine level measured by HPLC. qPCR analysis of hdc (G) and hcrt (H) transcript levels in 3 dpf larvae (p>0.05, n=3, Student′s t-test). Scale bar=100 μm.

Expression Data

Antibody:	Ab1-serotonin
Fish:	WT WT + MO2-manf + MO3-manf
Knockdown Reagents:	MO2-manf MO3-manf
Anatomical Term:	brain
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO2-manf + MO3-manf
Knockdown Reagents:	MO2-manf MO3-manf
Observed In:	dopaminergic neuron differentiation epinephrine metabolic process GABAergic neuron differentiation serotonin metabolic process
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 370(2), Chen, Y.C., Sundvik, M., Rozov, S., Priyadarshini, M., and Panula, P., MANF regulates dopaminergic neuron development in larval zebrafish, 237-249, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.