FIGURE

Fig. 2

ID

ZDB-FIG-120905-38

Publication

Bräutigam et al., 2011 - Vertebrate-specific glutaredoxin is essential for brain development

Other Figures

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Fig. 2

Knockdown of zfGrx2 suppressed formation of a neuronal network. Morpholino-induced knockdown of zfGrx2 led to loss of early HuC/D positive neurons between 22 and 24 hpf (A). As demonstrated by different techniques, all tested neuronal subgroups were affected at 24 hpf: glutamatergic excitatory interneurons, dopaminergic neurons, and secondary motor neurons (B). Embryos lacking zfGrx2 were not able to develop an axonal scaffold (C). Ac, anterior commissure; dlt, dorsal longitudinal tract; nMLF, nucleus of the medial longitudinal fascicle; poc, posterior commissure; tg, trigeminal ganglion; vlt, ventral longitudinal tract. Scale bar, 50 µm.

Expression Data

Gene:	EGFP
Antibody:	zn-5
Fish:	WT WT + MO1-glrx2 nns1Tg nns1Tg + MO1-glrx2
Knockdown Reagent:	MO1-glrx2
Anatomical Terms:	secondary motor neuron spinal cord neural tube neuron
Stage Range:	14-19 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-glrx2 nns1Tg + MO1-glrx2
Knockdown Reagent:	MO1-glrx2
Observed In:	central nervous system central nervous system development central nervous system projection neuron axonogenesis dopaminergic neuron glutamatergic neuron neuron secondary motor neuron white matter
Stage Range:	14-19 somites to Prim-5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA