FIGURE

Fig. 1

ID

ZDB-FIG-120405-87

Publication

Wang et al., 2012 - LAR Receptor Tyrosine Phosphatases and HSPGs Guide Peripheral Sensory Axons to the Skin

Other Figures

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Fig. 1

LAR Family Genes Are Expressed in Developing Somatosensory Neurons (A) Domain structure of zebrafish LAR family proteins. Two alternative splice forms of PTPRFa, differing by one fibronectin III repeat, were identified. Amino acid identities between the ectodomains and cytoplasmic domains separately are indicated. Ig, immunoglobulin-like domain; FN, fibronectin III repeat; TM, transmembrane domain; P, catalytic phosphatase domain. (B) Phylogenetic relationship between LAR family proteins. Zebrafish PTPRFa and PTPRFb clustered with the PTPRF family, whereas zebrafish PTPRDb was closest to other PTPRD family members. D, fruit fly; Hm, leech; h, human; m, mouse; x, Xenopus; z, zebrafish. ClustalW 1.81 was used to compare sequences, and FigTree v1.0 was used to create the tree. (C–H) Whole-mount in situ hybridization for LAR family members. (C)–(E) show dorsal views, rostral left, 28 hpf; (F)–(H) show lateral views, dorsal up, anterior left; embryo in (F) is 20-somite stage, and embryos in (G) and (H) are 24 hpf. Arrows indicate expression in trigeminal and RB sensory neurons. See also Figure S1.

Expression Data

Genes:	ptprdb ptprfa ptprfb
Fish:	WT
Anatomical Terms:	cranial ganglion hindbrain lateral line ganglion neuron olfactory placode Rohon-Beard neuron spinal cord ventral region trigeminal ganglion
Stage Range:	20-25 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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