FIGURE

Fig. 6

ID

ZDB-FIG-120405-80

Publication

Chernyavskaya et al., 2012 - The voltage-gated calcium channel CACNB2 (β2.1) protein is required in the heart for control of cell proliferation and heart tube integrity

Other Figures

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Fig. 6

Differentiation of cells in the first heart field and at the venous and arterial poles. A,B:fgf8 expression in the bilateral heart fields (arrows) at the four-somite stage (11.5 hours postfertilization [hpf]) is comparable in wild-type and morphant embryos. C,D: In situ hybridization with bmp4 on 48 hpf embryos, indicating normal expression of this marker at the venous end of the heart tube (arrowheads). Red dots outline the shape of the heart tube. E,F: In situ hybridization with vhmc on 30 hpf embryos, indicating the presumptive ventricle, as well as secondary heart field cells being added to the arterial pole (flanked by red dots).

Expression Data

Genes:	bmp4 fgf8a myh7
Fish:	WT WT + MO1-cacnb2a
Knockdown Reagent:	MO1-cacnb2a
Anatomical Terms:	lateral mesoderm presumptive bulbus arteriosus presumptive cardiac ventricle heart tube sinus venosus
Stage Range:	1-4 somites to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-cacnb2a
Knockdown Reagent:	MO1-cacnb2a
Observed In:	bulbus arteriosus primary heart field specification secondary heart field specification sinus venosus
Stage Range:	1-4 somites to Long-pec

Phenotype Detail

Acknowledgments

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