FIGURE

Fig. 1

ID

ZDB-FIG-120316-51

Publication

Sapetto-Rebow et al., 2011 - Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants

Other Figures

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Fig. 1

Phenotype of the zebrafish bloody minded (blm) mutant. A) Mutants can be first recognized at ~27 hpf when signs of malformation in the head are visible (red arrows). At 2 and 3 dpf, eyes are much smaller and the tail is bent dorsally. B) Plastic sections through the eye reveal apoptotic cells in the retina (red arrow) and in the brain at 27 hpf. There is no proper lamination of the retina and necrosis proceeds. Abbreviations: hpf - hours post fertilisation, dpf - days post fertilisation, R - retina, L - lens, PhL - photoreceptor layer, INL - inner nuclear layer, IPL - inner plexiform layer, GCL - ganglion cells layer.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	top2a^ucd3/ucd3 (AB)
Observed In:	central nervous system eye eye development forebrain head lens midbrain post-vent region retina retina layer formation
Stage Range:	Prim-5 to Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.