FIGURE

Fig. S4

ID

ZDB-FIG-120209-24

Publication

Zhang et al., 2012 - Zebrafish Models for Dyskeratosis Congenita Reveal Critical Roles of p53 Activation Contributing to Hematopoietic Defects through RNA Processing

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Fig. S4

Deficiencies of both dkc1 and nola1 lead to the defects of rRNA processing. (A) Schematic figure modified from previous report [29] shows the overview of rRNA processing. (B) A significant decrease of a precursor strand generating ITS1 and 18 S rRNA was detected in the lanes probed with ITS1 in both dkc1 morphant and nola1 mutant compared with wild type controls (arrows in a and b). The total amount of 18 S rRNA was reduced significantly as shown in the lanes probed with 18 S rRNA probe. The intensity of staining of 18 S rRNA relative to the background was measured using ImageJ program. In contrast, no obvious difference was detected in the lanes probed with ITS2 probe.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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