FIGURE

Fig. 6

ID

ZDB-FIG-111214-29

Publication

Teng et al., 2011 - Loss of Zebrafish lgi1b Leads to Hydrocephalus and Sensitization to Pentylenetetrazol Induced Seizure-Like Behavior

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Fig. 6

Analysis of c-fos expression as a marker for seizure-like behavior. Increased expression of c-fos in lgi1a (MO-E3), but not lgi1b (MO-E2), morphants compared with corresponding mismatch (mis) MO treatment. RNA and protein extracts from 3 dpf embryos injected with 3 ng of the indicated morpholinos or wildtype were used for semi-qRT-PCR (A) and western blot assays (B), respectively. When lgi1 morphants (MO-E2) were treated with PTZ, an increase in c-fos expression was observed. No increase in c-fos was seen when mismatch morphants (MO-E3mis) were treated with PTZ.

Expression Data

Gene:	fosab
Fish:	WT WT + MO1-lgi1b WT + MO2-lgi1a
Knockdown Reagents:	MO1-lgi1b MO2-lgi1a
Anatomical Term:	whole organism
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO2-lgi1a
Knockdown Reagent:	MO2-lgi1a
Observed In:	regulation of transmission of nerve impulse
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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