FIGURE

Fig. S6

ID

ZDB-FIG-110928-8

Publication

Liu et al., 2011 - Genetic Association for Renal Traits among Participants of African Ancestry Reveals New Loci for Renal Function

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Fig. S6

Dok6 and fndc1 knockdown in zebrafish embryos does not affect kidney development. (a–e) Uninjected control zebrafish embryos show normal glomerular and tubular morphology, as shown by in situ hybridization for the global kidney marker pax2a (a, inset showing lower-magnification image, with staining in both glomerulus and tubules), the podocyte markers wt1a (b) and nephrin (c), and the proximal and distal tubular markers slc20a1a (d) and slc12a3 (e). (f–o) Injection of dok6 (f–j) or fndc1 (k–o) morpholinos at the one-cell stage results in no significant changes in glomerular or tubular gene expression.

Expression Data

Genes:	nphs1 pax2a slc12a3 slc20a1a wt1a
Fish:	WT WT + MO1-dok6 WT + MO1-fndc1
Knockdown Reagents:	MO1-dok6 MO1-fndc1
Anatomical Terms:	podocyte pronephric distal late tubule pronephric glomerulus pronephric proximal convoluted tubule pronephric proximal straight tubule pronephric tubule
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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