FIGURE

Fig. 7

ID

ZDB-FIG-110920-75

Publication

Eames et al., 2011 - Mutations in fam20b and xylt1 Reveal That Cartilage Matrix Controls Timing of Endochondral Ossification by Inhibiting Chondrocyte Maturation

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Fig. 7

The uxs1 mutation is epistatic to cartilage and bone phenotypes of fam20b and xylt1 mutants.

A–H, Alcian blue/Alizarin red-stained 6 dpf ceratohyals. Compared to wild types (A,E), cartilage matrix of fam20b^b1127 (B) and xylt1^b1128 (F) mutants stained less with Alcian blue, but the perichondria of fam20b and xylt1 mutants stained more with Alizarin red (arrows) than in wild types. Similar to uxs1 mutants (C,G), uxs1;fam20b^b1127 (D) and uxs1;xylt1^b1128 (H) double mutants showed a greater decrease in Alcian blue staining of cartilage matrix than the decrease seen in fam20b and xylt1 mutants; also, Alizarin red staining (arrows) in uxs1 single mutant and uxs1;fam20b and uxs1;xylt1 double mutant perichondria was at wild-type levels. Abbreviations: bsr = branchiostegal ray.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fam20b^b1127/b1127 (AB) uxs1^w60/w60 xylt1^b1128/b1128 (AB) fam20b^b1127/b1127; uxs1^w60/w60 (AB) uxs1^w60/w60; xylt1^b1128/b1128 (AB)
Observed In:	ceratohyal cartilage perichondral bone
Stage:	Day 6

Phenotype Detail

Acknowledgments

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