FIGURE

Fig. 3

ID

ZDB-FIG-101223-5

Publication

Jackman et al., 2010 - Hedgehog signaling is required at multiple stages of zebrafish tooth development

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

Antisense RNA inhibition of shha, but not shhb, prevents the formation of mature teeth. Ventral views of the tooth-forming region of alizarin red stained 100 hpf embryos. Teeth develop normally in control morpholino injected embryos (A, left-side tooth shown in inset). Teeth are eliminated from shha MO injected embryos (B), but retained in embryos injected with an identical amount (12 ng) of the shhb morpholino (C). The combination of 6 ng shha MO with 18 ng shhb MO results in teeth forming closer to the midline and appearing slightly developmentally delayed but otherwise with normal morphology (D). Scale bar 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-shha WT + MO2-shhb WT + MO1-shha + MO2-shhb
Knockdown Reagents:	MO1-shha MO2-shhb
Observed In:	ceratobranchial 5 tooth odontogenesis tooth placode whole organism
Stage:	Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.