FIGURE

Fig. 1

ID

ZDB-FIG-101104-9

Publication

Uribe et al., 2010 - Id2a influences neuron and glia formation in the zebrafish retina by modulating retinoblast cell cycle kinetics

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

Id2a knockdown results in microphthalmia and defects in retinal lamination. (A,B) Id2a-MM-injected (control) (A) and Id2a-MO-injected (B) zebrafish embryos at 48 hpf display a reduction in eye and brain size. (C-H) Transverse histological sections of Id2a-MM and Id2a-MO retinas at 48 (C,F), 72 (D,G) and 120 (E,H) hpf. Id2a-MO eyes are smaller than Id2a-MM eyes, and the inner nuclear layer (INL) and outer nuclear layer (ONL) are not morphologically identifiable in Id2a-MO retinas at 72 hpf (G). (I) Measurements of absolute eye size along the anteroposterior (A/P) and dorsoventral (D/V) axes at 48 hpf. n=6 embryos; ^***, P<0.001. Error bars indicate ± s.e.m. Dorsal is up in all images. GCL, ganglion cell layer; L, lens. Scale bars: 150 μm in A,B; 80 μm in C-H.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-id2a
Knockdown Reagent:	MO1-id2a
Observed In:	brain eye retina layer formation retinal inner nuclear layer retinal outer nuclear layer
Stage Range:	Long-pec to Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development