FIGURE

Fig. 8

ID

ZDB-FIG-100616-119

Publication

Yao et al., 2010 - Atoh8, a bHLH transcription factor, is required for the development of retina and skeletal muscle in zebrafish

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Fig. 8

Transverse sections of Atoh8-MO treated embryo retina.

(A,C) Control eyes at 3dpf and 7dpf, respectively. (B,D) Eyes of MO-treated fish at 3dpf and 7dpf, respectively. The section shows that the retina did not develop normal neuronal stratification compared with the control at 3dpf. By 7pdf, lamination had formed in the treated embryos, however, the retinal size was remarkably reduced (D), and the number of retinal ganglion neurons was significantly reduced in MO fish (E). (p<0.001). Besides, the photoreceptor layer of the morphant was less elongated. In all panels, the ventral is down.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-atoh8 + MO5-tp53
Knockdown Reagents:	MO1-atoh8 MO5-tp53
Observed In:	retina retina layer formation retinal ganglion cell retinal neural layer
Stage Range:	Protruding-mouth to Days 7-13

Phenotype Detail

Acknowledgments

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