FIGURE

Fig. 4

ID

ZDB-FIG-100616-116

Publication

Yao et al., 2010 - Atoh8, a bHLH transcription factor, is required for the development of retina and skeletal muscle in zebrafish

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Fig. 4

Phenotypes of translation blocking morpholino (MO1) knockdown embryos.

(A–B)13-somite stage. (C–E) 24 hpf. (F–H) 48 hpf. (I–J) 72 hpf. (K–N) somite of mylz2-GFP transgenic zebrafish embryos at 48 hpf. (O–P) mylz2-GFP transgenic zebrafish embryos at 7dpf. A, C–D, F–G, I, K, M and O are Atoh8-MO treated embryos: A, C and F show severe abnormality, D, G, I, K, M and O show mild abnormality, and B, E, H, J, L, N and P are control-MO treated embryos. Atoh8-MO-treated embryos show shrunken eyes and head, a curved body axis with indistinct somite boundaries and yolk extension, accompanied by a U-shaped somite formation. In addition, the branchial arches are greatly reduced(O–P). In all panels but P, the dorsal view is up and the anterior is to the left. P shows the ventral view and the anterior to the left. Abbreviations: re, retina; sm, somite; ba, branchial arches.

Expression Data

Gene:	GFP
Fish:	gz5Tg + MO1-atoh8 + MO5-tp53 gz5Tg + MO5-tp53
Knockdown Reagents:	MO1-atoh8 MO5-tp53
Anatomical Terms:	skeletal muscle somite
Stage Range:	Long-pec to Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-atoh8 + MO5-tp53
Knockdown Reagents:	MO1-atoh8 MO5-tp53
Observed In:	blood circulation brain extension eye head pharyngeal arch 3-7 post-vent region somite somite border whole organism anterior-posterior axis
Stage Range:	10-13 somites to Protruding-mouth

Phenotype Detail

Acknowledgments

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