FIGURE

Fig. 2

ID

ZDB-FIG-100309-76

Publication

Lorent et al., 2010 - Reiterative use of the notch signal during zebrafish intrahepatic biliary development

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Fig. 2

Development of hepatocyte canaliculi and intrahepatic biliary network. Developmental pattern of the 2F11 epitope (A-E) and Mdr epitope, a canalicular transporter (A′-E′) with overlap of the two markers (A″-E″). The length and number of the canaliculi increases between 60 and 120 hpf. The overlap of the two markers shows that each canaliculus develops in close association with the 2F11-positive biliary epithelia. Each canaliculus drains into a single intrahepatic bile duct. The ducts associated with many of the canaliculi in the 120-hpf sample are out of the plane of focus. F, F′, F″: Comparable confocal projections through the liver of a larva immunostained with the keratin-18 and Mdr antibodies. Note overlap (yellow) of the keratin-18 epitope in the terminal ductules with the Mdr protein in the canalicular membrane.

Expression Data

Antibodies:	Ab-2F11 Ab1-krt18 Ab1-mdr
Fish:	TL
Anatomical Terms:	bile canaliculus bile ductule intrahepatic bile duct epithelial cell liver and biliary system liver and biliary system epithelial cell
Stage Range:	Pec-fin to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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