FIGURE

Fig. 6

ID

ZDB-FIG-100304-25

Publication

Brown et al., 2010 - Nlcam modulates midline convergence during anterior neural plate morphogenesis

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Fig. 6

nlcam loss of function causes delayed convergence. (A–D) At 4SS, a deep cleft at the midline in nlcam ATG-MO injected (0.3 mM) embryos (B) indicates that forebrain cells have not yet converged to the midline, as they have in control embryos (A). This is confirmed by in situ hybridisation against emx3 (A′, B′). This phenotype is transient, as demonstrated by the recovered forebrain morphology by 8SS (C, D). (E–G) Graphs show selected statistics for forebrain cell convergence from a single dataset. (E) Position of cells relative to the midline. (F) MSD along the ML axis. (G) Speed along the ML axis. Blue = wt cells; red = nlcam-MO.

Expression Data

Gene:	emx3
Fish:	WIK/AB WIK/AB + MO1-alcamb
Knockdown Reagent:	MO1-alcamb
Anatomical Terms:	forebrain neural keel forebrain neural rod
Stage Range:	1-4 somites to 5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WIK/AB + MO1-alcamb
Knockdown Reagent:	MO1-alcamb
Observed In:	dorsal convergence forebrain cell migration forebrain neural keel
Stage:	1-4 somites

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 339(1), Brown, K.E., Keller, P.J., Ramialison, M., Rembold, M., Stelzer, E.H., Loosli, F., and Wittbrodt, J., Nlcam modulates midline convergence during anterior neural plate morphogenesis, 14-25, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.