FIGURE

Fig. 6

ID

ZDB-FIG-090710-8

Publication

Roberts et al., 2009 - Apical polarity protein PrkCi is necessary for maintenance of spinal cord precursors in zebrafish

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Fig. 6

Loss of protein kinase C, iota (PrkCi) function causes formation of excess oligodendrocyte progenitor cells (OPCs) from pMN precursors. Panels show frames captured from time-lapse videos of wild-type and has^-/- embryos carrying the Tg(olig2:egfp) reporter. Dorsal is up and time elapsed from beginning of imaging at 50 hours postfertilization (hpf) is indicated in upper right corners of panels. Brackets mark pMN precursor domain in ventral spinal cord. A: Wild-type embryo. Arrowheads mark OPCs migrating dorsally from the ventral pMN precursor domain. B: has^-/- embryo. More OPCs (arrowheads) emerge from the pMN domain than in wild-type over a similar period of time. C: Quantification of dorsally migrating OPCs. Data were obtained from time-lapse movies of 6 wild-type and 5 has^-/- embryos. Error bars represent SEM. Statistical significance was determined using Student′s t-test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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