FIGURE

Fig. 5

ID

ZDB-FIG-090127-24

Publication

Targoff et al., 2008 - Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number

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Fig. 5

nkx genes play a critical role in early steps of heart tube extension. In situ hybridization depicts expression of cmlc2 (A,B), vmhc (C,D), and amhc (E,F) in wild-type (A,C,E) and nkx-deficient (B,D,F) embryos. Embryos viewed dorsally, anterior to the top, at 26 hpf. (A,B) nkx-deficient embryos exhibit prominent defects in heart tube extension, including a splayed and disorganized inflow region and an unusually compact outflow region. (C,D) In nkx-deficient embryos, the ventricular portion of the heart tube is abnormally short and wide. (E,F) In nkx-deficient embryos, the atrial portion of the heart tube is broad and sprawling.

Expression Data

Genes:	myh6 myh7 myl7
Fish:	WT WT + MO1-nkx2.7 + MO2-nkx2.5
Knockdown Reagents:	MO1-nkx2.7 MO2-nkx2.5
Anatomical Terms:	heart tube presumptive cardiac ventricle heart tube
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-nkx2.7 + MO2-nkx2.5
Knockdown Reagents:	MO1-nkx2.7 MO2-nkx2.5
Observed In:	atrium cardiac ventricle embryonic heart tube development heart looping heart tube
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 322(2), Targoff, K.L., Schell, T., and Yelon, D., Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number, 314-321, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.