FIGURE

Fig. 9

ID

ZDB-FIG-090113-17

Publication

Esterberg et al., 2009 - dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity

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Fig. 9

Manipulation of PPR-inducing signals can rescue the otic phenotype of Dlx3b/4b morphants. (B) Dlx3b/4b morphants display a small, circular otic vesicle that lacks otoliths. (C,D) The otic phenotype of Cv2 morphants resembles that of Dlx3b/4b morphants (B), and is not significantly affected by the additional loss of Dlx3b/4b (D). (E,F) Ectopic expression of cv2 mRNA can rescue the Dlx3b/4b otic phenotype (F). (G–L) While heat shock of tBR embryos (G), knockdown of Bmp4 (I), or ectopic fgfr1 expression (K) does not affect ear morphology, each is able to partially rescue the otic phenotype of Dlx3b/4b morphants (H,J,L). All embryos are 30 hpf; lateral views, with anterior to the left.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-bmp4 WT + MO1-bmper WT + MO5-dlx3b + MO5-dlx4b WT + MO1-bmp4 + MO5-dlx3b + MO5-dlx4b WT + MO1-bmper + MO5-dlx3b + MO5-dlx4b
Knockdown Reagents:	MO1-bmp4 MO1-bmper MO5-dlx3b MO5-dlx4b
Observed In:	inner ear otolith
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 325(1), Esterberg, R., and Fritz, A., dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity, 189-199, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.