FIGURE

Fig. 8

ID
ZDB-FIG-081007-42
Publication
Russek-Blum et al., 2008 - Dopaminergic neuronal cluster size is determined during early forebrain patterning
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Fig. 8

Canonical Wnt pathway components restrict DA cell number. (A-E) Lateral views of zebrafish embryos that were injected with vehicle solution (WT, n=71; A), wnt8b morpholino (MO) (n=20; B), fz8a MO (n=11; C) or lef1 MO (n=18; D) and of the lef1-deficient X8 deletion mutant (n=18; E). Embryos were fixed at 24 hpf and subjected to in situ hybridization with a dat probe. The result of the double knockdown of wnt8b and fz8a (n=44) is presented in F. (F) Bar chart summarizing average cell counts of DA group 2 neurons in the genetic backgrounds shown in A-E. (G,H) Lateral views (anterior to the left) of embryos that were injected with vehicle solution (G) or wnt8b MO (H). Embryos were fixed at 24 hpf and subjected to whole-mount in situ hybridization with an RNA probe directed against barhl2. Scale bar: 50 μm.

Expression Data
Genes:
Fish:
Knockdown Reagents:
Anatomical Terms:
Stage: Prim-5

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Knockdown Reagents:
Observed In:
Stage: Prim-5

Phenotype Detail
Acknowledgments
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