FIGURE

Fig. S1

ID

ZDB-FIG-070920-18

Publication

Hans et al., 2007 - Changes in retinoic acid signaling alter otic patterning

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Fig. S1

Teratogenic doses (1 μM), but not 20 nM, RA alter the expression of early markers of anterioposterior axis specification. (A-F) In comparison to controls, expression of the anterior neural plate markers six3a (A-C) and otx2 (D-F) is unaffected by 20 nM RA but is completely abolished in the presence of a teratogenic dose. (G-L) By contrast, expression of the posterior neural plate markers hoxb1b (G-I) and gbx1 (J-L) is greatly expanded in embryos treated with a teratogenic dose of RA, whereas embryos treated with 20 nM RA show only a mild or no anterior expansion in comparison to control embryos. Scale bar: 90 μm.

Expression Data

Genes:	gbx1 hoxb1b otx2b six3a
Fish:	AB
Condition:	chemical treatment: all-trans-retinoic acid
Anatomical Terms:	anterior neural plate anterior presumptive neural plate neural plate presumptive hindbrain
Stage Range:	75%-epiboly to Bud

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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