FIGURE

Fig. 4

ID

ZDB-FIG-070620-42

Publication

Hans et al., 2007 - Changes in retinoic acid signaling alter otic patterning

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Fig. 4

Increased RA signaling compromises lens specification. (A-F) Assessed both by morphology at 50 hpf (DIC microscopy, A-C) and cx44.1 expression at 24 hpf (D-F), the lens is reduced in size or completely lost after the application of 10 or 20 nM RA, compared with wild-type embryos. (G-I) Compromised lens specification is already evident at preplacodal stages (five-somite stage, 5S), as indicated by pax6b labeling. (A-C) Lateral views of live eyes with anterior to the left and dorsal towards the top. (D-I) Dorsal views with anterior towards the top. Scale bar: 30 µm for A-C; 50 µm for D-F; 35 µm for G-I.

Expression Data

Genes:	gja8b pax6b
Fish:	AB
Condition:	chemical treatment: all-trans-retinoic acid
Anatomical Terms:	optic vesicle solid lens vesicle
Stage Range:	5-9 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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