FIGURE

Fig. 6

ID

ZDB-FIG-070815-18

Publication

Schibler et al., 2007 - A screen for genetic defects of the zebrafish ear

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Fig. 6

Early patterning of hako mimi^jj59, mikre ucho^jj108, and ale ucho^jj410 mutant ears. The expression of the anterior marker, pax5 (B, H, N, T), does not show any differences between wild-type and mutants. The same is true for pax2a (C, I, O, U), otomp (D, J, P, V), eya1 (E, K, Q, W), and follistatin (fst) (F, L, R, X). The msxc probe (A, G, M, S) is a marker of cristae. Its expression is absent in both mikre ucho^jj108 (M), and hako mimi^jj59 (G) mutants, but remains wild-type in ale ucho^jj410 (S). pax5, pax2a, otomp, and eya1 expression patterns were evaluated at 24 hpf, the fst expression at 36 hpf, and msxc at 48 hpf. In the pax2a column, expression is shown from the dorsal side. In all other columns, anterior is left and dorsal is up. Images of mxsc and otomp are at the same magnification. Likewise, the images of pax5, pax2a, eya1, and fst were collected at the same magnification. Scale bars equal 50 &mum.

Expression Data

Genes:	eya1 fsta msx3 otomp pax2a pax5
Fish:	AB jag1b^jj59/jj59 (AB) lmx1bb^jj410/jj410 (AB) mko^jj108/jj108 (AB)
Anatomical Terms:	anterior crista primordium head lateral crista primordium otic vesicle posterior crista primordium
Stage Range:	Prim-5 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 124(7-8), Schibler, A., and Malicki, J., A screen for genetic defects of the zebrafish ear, 592-604, Copyright (2007) with permission from Elsevier. Full text @ Mech. Dev.