The zebrafish dou yanmi234 mutation causes reduction in eye size. A-H: The small eye phenotype in the mutants is evident at 2 days postfertilization (dpf). The mutant eyes remain smaller than the wild-type eyes at subsequent developmental stages. I: The dou yanmi234 mutation does not lead to reduction of body size in mutants. In a dorsal view at 4 dpf, the body of this mutant fish (right) is slightly longer than that of a wild-type sibling (left). J: A lateral view of a wild-type (top) and mutant fish (bottom) at 3 dpf shows no paracardiac edema in dou yan mutants. K: A bulk segregant mapping analysis revealed that the dou yan gene localizes to a genomic region that is flanked by markers Z11532 and Z26044 on chromosome 21.
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