FIGURE

Fig. 2

ID

ZDB-FIG-070608-6

Publication

Hall et al., 2007 - The zebrafish candyfloss mutant implicates extracellular matrix adhesion failure in laminin {alpha}2-deficient congenital muscular dystrophy

Other Figures

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Fig. 2

Unlike in dystrophin-deficient sap embryos, detached fibers in caf embryos do not show uptake of EBD, indicating that the sarcolemma is not compromised. (A) EBD within caf homozygotes is not taken up by a recently detached fiber in a homozygous caf embryo (arrowhead). (B) EBD can be seen to pool in a large myotomal lesion created by multiple retracting fibers (arrowhead). Retracted fibers themselves remain impermeable to EBD (arrow). (C) Damaged fibers in homozygous sap embryos are infiltrated by EBD before detachment. (D) EBD-positive retracted fiber in a sap embryo. (i) fluorescence, (ii) DIC, and (iii) merge. All images represent 72-hpf embryos, lateral views with anterior to the left.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dmd^{ta222a/ta222a} lama2^{teg15a/teg15a}
Observed In:	myotome sarcolemma
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA