FIGURE

Fig. 7

ID

ZDB-FIG-070307-75

Publication

Hans et al., 2007 - Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

Ectopic otic induction after fgf8 expression at late gastrulation stages requires both, Foxi1 and Dlx3b. (A-D) Inactivation of Dlx3b or Foxi1 in wild-type embryos by morpholino injection (MO) leads to a reduction of ear size in comparison to wild-type embryos, and combined loss of Dlx3b and Foxi1 results in loss of all indications of otic specification. (E-H) Ear size reduction by depletion of Dlx3b or Foxi1 but not combined loss of Dlx3b and Foxi1, can be partially rescued in transgenic hsp:fgf8 embryos heat shocked at late gastrulation stages. Lateral views of otic vesicles hybridized with starmaker at 24h with anterior to the left and dorsal towards the top. Scale bar: 40 μm.

Expression Data

Gene:	stm
Fish:	WT WT + MO1-dlx3b WT + MO2-foxi1 b1193Tg (AB) WT + MO1-dlx3b + MO2-foxi1 b1193Tg + MO1-dlx3b (AB) b1193Tg + MO2-foxi1 (AB) b1193Tg + MO1-dlx3b + MO2-foxi1 (AB)
Condition:	heat shock
Knockdown Reagents:	MO1-dlx3b MO2-foxi1
Anatomical Term:	otic vesicle
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-dlx3b WT + MO2-foxi1 WT + MO1-dlx3b + MO2-foxi1 b1193Tg + MO1-dlx3b (AB) b1193Tg + MO2-foxi1 (AB) b1193Tg + MO1-dlx3b + MO2-foxi1 (AB)
Condition:	heat shock
Knockdown Reagents:	MO1-dlx3b MO2-foxi1
Observed In:	otic vesicle
Stage:	Prim-5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.