FIGURE

Fig. 4

ID

ZDB-FIG-060823-7

Publication

Rau et al., 2006 - Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage and ear development

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Fig. 4

Neural crest and craniofacial phenotypes of tpd mutants. (A, C, E, G) WT; (B, D, F, H) tpd mutants. (A, B) Expression of col2a1 in the head at 68 hpf, lateral view. (C, D) Expression of dlx2a in the pharyngeal arches at 24 hpf, dorsal view. (E, F) Alcian blue-stained cartilages at 5 dpf, ventral view. (G, H) Sox10 Expression in the trunk region of wild type (G) and tpd mutants (H). Note the absence of ventrally migrating Sox10-expressing cells in tpd mutants. (I, J) Anti-Hu immunostaining at 3 dpf, lateral view of the trunk. Arrows indicate the position of DRGs. Note the absence of DRGs in tpd mutants.

Expression Data

Genes:	col2a1a dlx2a sox10
Fish:	WT med12^{t25870/t25870}
Anatomical Terms:	eye otic vesicle pharyngeal arch trunk neural crest
Stage Range:	Prim-5 to Pec-fin

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 296(1), Rau, M.J., Fischer, S., and Neumann, C.J., Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage and ear development, 83-93, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.