FIGURE

Fig. 2

ID

ZDB-FIG-051122-3

Publication

Heicklen-Klein et al., 2004 - T-box binding sites are required for activity of a cardiac GATA-4 enhancer

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Fig. 2

The GATA-4 promoter recapitulates the endogenous expression pattern during cardiogenesis. (A) In situ hybridization of GATA-4 RNA stains a stripe of cells just dorsal to the yolk (large black arrowhead). (B) GFP expression controlled by the 14.8-kb GATA-4 promoter in the heart also forms a similar stripe in the LPM resembling that in A (large white arrowhead). Note that the posterior extent of the GFP-positive heart precursors (arrow) overlaps with the anterior extend of GFP-positive cells in the notochord (small arrowhead). (C) Phase image corresponding to B. All images are lateral views. E = eye, N = notochord, S = somites, TB = tailbud and Y = yolk.

Expression Data

Gene:	gata4
Fish:	WT
Anatomical Terms:	heart primordium tail bud
Stage:	10-13 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 267(2), Heicklen-Klein, A., and Evans, T., T-box binding sites are required for activity of a cardiac GATA-4 enhancer, 490-504, Copyright (2004) with permission from Elsevier. Full text @ Dev. Biol.