Genomic Feature
sa1199
- ID
- ZDB-ALT-120411-43
- Name
- sa1199
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation
- Protocol
- adult males treated with ENU
- Lab of Origin
- Stemple Lab
- Current Source
-
European Zebrafish Resource Center (EZRC)
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Zebrafish International Resource Center (ZIRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 24: 17349235 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T in Exon 2 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Arg>Stop at position 18 (1)
- Flanking Sequence
-
AAACCGCGGTAAATCTTGAAACCAGTTATTTTGCCATGCCTAAGTGTGCCTGCATATGCTGAAAACACCAAACGCATAATGTTAGGAAAAAGTGTGTGTAGTAAATGAAAGTTCATTAACACTTACATGAATAGGTAGAGCATGAAAACGTATATGGTATGGTTGTTGCAGTTCACAGACTCAACAGTTTGAATAGATGTGCACTCCTACGTTTGATACAATTGTTTACACTTTTGTCACATTCTACATTATGCAGCTAATTCAGTTTTTAGAGATGGATTTTAGAATTCAGTCATTACCATCATGGACATCTTTGGGTCCTATGTTTATTTGTAGTAGTTTTCAATCATATACCAAAGTCAAAAGGAAAACCACCTAACCTTAATGTTGAATGGTTCTATATTAATCTAAAGTGAAATCTAAAACTGTACTCTGTCTATAGGGAAACCATGGGATTGACCGGGAGGAAATCGGAGAAGGGTCCTGTTTGCTGGAGGCGG
C/T GAGTGAAGTCTGAGTACATGCGGCTGCGGCAGCTCAAACGCTTCAGGAGGGCAGACGAGGTCAAGGTAATCCATGGGCTAGTACAGCAGACATACTGCTGCTTGTGTAGAGTTTGGTGTTGGTAATGTTTTAGTTTTCACATAATGAGTCCAGTTGCATGTGTGTAAAACACAAATGAATCAAAGTTTTATTAGAACAACCATGTTGACTTTTTTTGTGTGTGTGAACGTCCTGTAATTGCTACGTATTTTCTTACTGAACAGAGCATGTTCAGCTCCAACAGACAAAAAATATTGGAGCGTACTGACATCTTAAATCAGGAATGGAAACTGAGGCGGATACAGCCTGTTCATATTATGACACCTGTGAGCTCCTTGCGTGGAACCAGAGAGGTTAGATCAATCTCGTTTCTGTTTTTTAATATATGTCCGTTAATATTTTATTGTTAAATGCATTATTGTTTTGGCTGCACAGTGTTAAAAGTGAAAGGGTCATCATTT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| ezh2sa1199/sa1199 | Homozygous | ♀+/- ♂+/- | 4 figures  from Zhong et al., 2018 | 7 figures from 2 publications | |
| ezh2sa1199/sa1199 (TL) | Homozygous | ♀+/- ♂+/- | 2 figures from 2 publications | Fig. 3 from San et al., 2019 | |
| ezh2sa1199/+ | Heterozygous | ♀+/- ♂+/- | Fig. 2 from San et al., 2019 | ||
| ezh2sa1199/sa1199; hkz04tTg | Complex | Fig. 8 from Zhong et al., 2018 | Fig. 8 from Zhong et al., 2018 | ||
| ezh2sa1199/sa1199; i114Tg | Complex | Fig. 7 from Zhong et al., 2018 | Fig. 7 from Zhong et al., 2018 | ||
| ezh2sa1199/sa1199; nz117Tg | Complex | Fig. 7 from Zhong et al., 2018 | Fig. 7 from Zhong et al., 2018 | ||
| ezh2sa1199/sa1199; sd2Tg | Complex | Fig. 7 from Zhong et al., 2018 | Fig. 7 from Zhong et al., 2018 | ||
| ezh2sa1199/sa1199; zf169Tg | Complex | Fig. 8 from Zhong et al., 2018 | Fig. 8 from Zhong et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- San, B., Rougeot, J., Voeltzke, K., van Vegchel, G., Aben, M., Andralojc, K.M., Flik, G., Kamminga, L.M. (2019) The ezh2(sa1199) mutant zebrafish display no distinct phenotype. PLoS One. 14:e0210217
- Zhong, Y., Ye, Q., Chen, C., Wang, M., Wang, H. (2018) Ezh2 promotes clock function and hematopoiesis independent of histone methyltransferase activity in zebrafish. Nucleic acids research. 46(7):3382-3399
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