- Title
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Iron supplementation inhibits hypoxia-induced mitochondrial damage and protects zebrafish liver cells from death
- Authors
- Hu, R., Li, G., Xu, Q., Chen, L.
- Source
- Full text @ Front. Physiol.
Hypoxia stress affects cell growth, ROS production and iron metabolism in cytoplasma and mitochondria. |
Iron supplementation could improve the survival activity of ZFL cells under hypoxia stress, but iron chelation and inhibition of ferroptosis could not. |
Iron supplementation can increase ROS level and reduce mitochondrial damage in cells under hypoxia stress. |
RNA-seq analysis revealed significant transecriptomic changes in hypoxia ZFL cell. |
Iron supplementation increases the proportion of functioning mitochondria. |
Response of ZF4 cells to hypoxic stress. |