FIGURE SUMMARY
Title

Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4)

Authors
Thornton, J.E., Du, P., Jing, L., Sjekloca, L., Lin, S., Grossi, E., Sliz, P., Zon, L.I., Gregory, R.I.
Source
Full text @ Nucleic Acids Res.
Fig. 8

Inhibition of zebrafish Zcchc6/11 genes results in improper Hox expression and embryonic development. (a) The zcchc6 or zcchc11 morphant embryos display multiple defects at 48 hpf, including degeneration of somites, failure of tail elongation, pericardial edema and developmental delay. RT-PCR was used to measure the relative knockdown of Zcchc6 and Zcchc11. PCR products were resolved using agarose gel electrophoresis and visualized by ethidium bromide staining (b) Quantitative PCR analysis (on 24-h embryos) shows the reduction of several Hox genes. Blue bars are control and red bars represent Zcchc11 MO (candd) Hoxb8b was reduced in Zcchc6 and Zcchc11 morphant embryos at 24 hpf. The numbers indicated in the right hand corner of each picture: the number of affected embryos similar to what is shown (left) and the total number of observed embryos (right).

EXPRESSION / LABELING:
Gene:
Fish:
Knockdown Reagents:
Anatomical Term:
Stage: Prim-5
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage: Long-pec
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nucleic Acids Res.
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