Moro Lab

My group is currently involved in using zebrafish to model lysosomal storage disorders (LSD), particularly the Hunter syndrome and Gaucher disease. We are exploiting several in vivo approaches to dissect early molecular events involved in cellular abnormalities detected in fish morphants and mutants for lysosome-associated proteins. We are particularly focused in the bone and heart compartments, as in some of the investigated disorders these tissues are severely compromised.
We are also trying to translate the observed results in mouse models and perform also a preliminary molecular characterization of affected patients.