Person
Moro, Enrico
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Biography and Research Interest
My group is currently involved in using zebrafish to model lysosomal storage disorders (LSD), particularly the Hunter syndrome and Gaucher disease. We are exploiting several in vivo approaches to dissect early molecular events involved in cellular abnormalities detected in fish morphants and mutants for lysosome-associated proteins. We are particularly focused in the bone and heart compartments, as in some of the investigated disorders these tissues are severely compromised.
We are also trying to translate the observed results in mouse models and perform also a preliminary molecular characterization of affected patients.
We are also trying to translate the observed results in mouse models and perform also a preliminary molecular characterization of affected patients.
Non-Zebrafish Publications
Wang, Z., Moro, E., Kovacs, K. Yu, R. and Melmed, S. Pituitary tumor transforming gene-null mice exhibit impaired pancreatic beta cell proliferation and diabetes. Proc Natl Acad Sci USA 2003, Mar 18;100(6):3428-32Ferlin, A., Moro, E., Rossi, A., Dallapiccola, B., and Foresta, C. The human Y chromosome's azoospermia factor b(AZFb) region: sequence, structure, and deletion analysis in infertile men. J Med Genet 2003; 40: 18-24
Foresta, C., Bettella, A., Moro, E., Rossato, M., Merico, M., Garolla, A., and Ferlin, A. Inhibin B plasma concentrations in infertile patients with DAZ gene deletions treated with FSH. Eur J Endocrinol 2002 Jun;146(6):801-6.
Foresta, C., Bettella, A., Ferlin, A., Garolla, A., Moro, E., Baldinotti, F., Simi, P., and DallaPiccola, B. Response to local dihydrotestosterone treatment in a patient with partial androgen-insensitivity syndrome due to a novel mutation in the androgen receptor gene. American Journal of Medical Genetics, 2002, Jan 22, 107(3): 259-260.
Ferlin, A., Moro, E. (first coauthor), Rossi, A., and Foresta, C. A novel approach for the analysis of DAZ gene copy number in severely idiopathic infertile men. J Endocrinol Invest 2002 Jan;25(1):RC1-3
Marin, P., Ferlin, A., Moro, E., Rossi, A., Bartoloni, L., Rossato, M., and Foresta, C. A novel INSL3 mutation associated with human cryptorchidism. American Journal of Medical Genetics. 2001, 103 (4): 348-349.
Foresta, C., Moro, E., and Ferlin, A. Prognostic Value of Y deletion analysis. Human Reproduction 2000, 16 (8):1543-7
Foresta, C., Bettella, A., Moro, E., Merico, M., Roverato, A., and Ferlin, A. Sertoli cell function in infertile patients with and without microdeletions of the azoospermia factor on the Y chromosome. Journal of Clinical Endocrinology and Metabolism; 86 (6): 2414-2419. 2001
Marin, P., Ferlin, A., Moro, E., Garolla, A., and Foresta, C. Different insulin-like 3 (INSL3) gene mutations not associated with human cryptorchidism. Journal of Endocrinological Investigation, 2001, 24(4) RC13-5.
Maurizio, O., Romina, G., Lorenza, Z., Alessandro, N., Maurizio, M., Enrico, M., and Carlo, F. Evidence for FSH-dependent upregulation of spata2 (spermatogenesis-associated protein 2) Biochem Biophys Res Commun. Apr 27;283(1):86-92. 2001.
Foresta, C., Moro, E., and Ferlin, A. Y chromosome microdeletions and alterations of spermatogenesis. Endocrine Reviews Apr;22(2):226-39. 2001.
Ferlin, A., Moro, E., Rossi, A., and Foresta, C. CDY1 analysis in infertile patients with DAZ deletions. Journal of Endocrinological Investigation, 24: RC4-62, 2001.
Moro, E., Ferlin, A., Yen Hsiao, P., Guanciali Franchi, P., Palka, G., and Foresta, C. Male Infertility caused by a de novo partial deletion of the DAZ cluster on the Y chromosome. Journal of Clinical Endocrinology and Metabolism, 85: 4069-73, 2000.
Foresta, C., Moro, E., Rossi, A., Rossato, M., Garolla, A., and Ferlin, A. Role of the AZFa candidate genes in male infertility. Journal of Endocrinological Investigation,23, 646-51 2000.
Paracchini, S., Stuppia, L., Gatta, V., Palka, G., Moro, E., Foresta, C., Mengual, L., Oliva, R., Ballesc�, J.L., Kremer, J.A.M., van Golde, R.J.T., Tuerlings, J., Hargreave, T., Ross, A., Cooke, H., Huellen, K., Vogt, P.H., and Tyler-Smith, C. Y-chromosomal DNA haplotypes in infertile European males carrying Y-microdeletions. Journal of Endocrinological Investigation,23, 671-6. 2000.
Moro, E., Marin, P., Rossi, A., Garolla, A., and Ferlin, A. Y chromosome microdeletions in infertile men with varicocele. Molecular and Cellular Endocrinology. Mar 3; 161(1-2):67-71, 2000.
Foresta, C., Ferlin, A., and Moro, E. Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility. Human Molecular Genetics, May 1;143(3): 1161-9, 2000.
Foresta, C., Ferlin, A., Moro, E., and Scandellari, C. Y chromosome. Lancet 355, 234-235, 2000.
Simoni, M., Bakker, E., Eurlings, M.C.M., Matthijs, G., Moro, E., Muller, C.R., and Vogt, P.H.. Laboratory Guidelines for molecular diagnosis of for molecular diagnosis of ?chromosomal microdeletions. International Journal of Andrology 22:292-299, 1999.
Foresta, C., Moro, E., Garolla, A., Onisto, M., and Ferlin, A. Y chromosome microdeletion in cryptorchidism and idiopathic infertility. Journal of Clinical Endocrinology and Metabolism, 84: 3660-3665, 1999.
Ferlin, A., Moro, E., Onisto, M., Toscano, E., Bettella, A., and Foresta, C. Absence of testicular DAZ gene expression in idiopathic severe testiculopathies. Human Reproduction, 14:2286-2292, 1999.
Ferlin, A., Moro, E., Garolla, A., and Foresta, C. Human male infertility and Y-chromosome deletions: role of the AZF-candidate genes: DAZ, RBM, and DFFRY. Human Reproduction, 14:1710-1716, 1999.
Foresta, C., Ferlin, A., Garolla, A., Moro, E., Pistorello, M., Barbaux, S., and Rossato, M. High frequency of well-defined Y-chromosome deletions in idiopathic Sertoli cell-only syndrome. Human Reproduction, 13: 302-307, 1998.
Ferrari, S., Moro, E., Pettenazzo, A., Zacchello, F., and Scarpa, M. Exgen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo. Gene Therapy,4:1100-1106, 1997.