Lab
Evans Lab
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Statement of Research Interest
Function and Regulation of GATA Transcription Factors for Embryonic Development, Organ Morphogenesis, and Cell Differentiation.
The lab focuses on a small group of vertebrate transcriptional regulatory proteins called GATA factors. These proteins function to regulate a variety of cell specification, differentiation, and morphogenetic programs during embryogenesis and throughout life. We are particularly interested in the embryonic signaling programs that regulate the genes encoding GATA factors, including the Bone Morphogenetic Proteins (BMPs) and WNTs. There are several major programs in the lab, studying erythropoiesis (red blood cell development) and cardiogenesis (heart development). We also use murine and human ESC models to understand the role of GATA factors in various disease states. Recently we are developing projects in chemical biology and stem cells in aging.
The lab focuses on a small group of vertebrate transcriptional regulatory proteins called GATA factors. These proteins function to regulate a variety of cell specification, differentiation, and morphogenetic programs during embryogenesis and throughout life. We are particularly interested in the embryonic signaling programs that regulate the genes encoding GATA factors, including the Bone Morphogenetic Proteins (BMPs) and WNTs. There are several major programs in the lab, studying erythropoiesis (red blood cell development) and cardiogenesis (heart development). We also use murine and human ESC models to understand the role of GATA factors in various disease states. Recently we are developing projects in chemical biology and stem cells in aging.
Lab Members